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What is Trexall used for? Trexall (methotrexate) is an antimetabolite drug that is used to treat some cancers, severe skin diseases such as severe psoriasis, and to treat forms of rheumatoid arthritis. Trexall is available in generic form as methotrexate.
What causes methotrexate toxicity? Methotrexate toxicity develops due to increased patient susceptibility during treatment, excessive parenteral or intrathecal administration, therapeutic errors by patients (e.g. taking MTX orally daily instead of weekly), self-administration to induce abortion, or intentional oral overdoses.
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